Quinine disposition kinetics.

Metabolism and disposition kinetics of nicotine.

Nicotine is of importance as the addictive chemical in tobacco, pharmacotherapy for smoking cessation, a potential medication for several diseases, and a useful probe drug for phenotyping cytochrome P450 2A6 (CYP2A6). We review current knowledge about the metabolism and disposition kinetics of nicotine, some other naturally occurring tobacco alkaloids, and nicotine analogs that are under develo...

Bioavailability and Disposition Kinetics of Amoxicillin

.. OBJECTIVE: The study was planned to observe the bioavailability and disposition kinetics of amoxicillin in adult rabbits (irrespective of sex) under healthy and dehydrated conditions. Design: Comparative. Place and duration of study: The study was conducted at the department of pharmacology, University of Veterinary and Animal Sciences, Lahore from April 2013 to October 2013. Methodology: In...

Modeling Kinetics of Subcellular Disposition of Chemicals

Disposition Kinetics of Taxanes in Peritoneal Dissemination

Treatment of cancers in the abdominal cavity, such as peritoneal dissemination, is difficult, but in principle intraperitoneal administration of anticancer drugs is expected to be preferable to systemic administration. Taxane anticancer drugs are used to treat gastric cancer patients with peritoneal dissemination. They are administered as micellar preparations, Taxol and Taxotere, which consist...

Disposition kinetics of kanamycin in mules

The disposition kinetics of kanamycin was investigated following an injection of a single intravenous dose 5 mg/kg body mass in healthy adult female mules. Blood samples collected at various time intervals post-medication were analyzed for kanamycin by microbiological assay. The plasma drug concentration versus time data was best fitted by a biexponential expression. Macro-kinetic parameters we...